Anti-idiotypic antibodies directed against anti-HBs among the patients with chronic hepatitis B.
نویسندگان
چکیده
منابع مشابه
Clinical and Virological Characteristics of Chronic Hepatitis B Patients with Coexistence of HBsAg and Anti-HBs
Coexistence of hepatitis B surface antigen (HBsAg) and antibody against HBsAg (anti-HBs) comprises an atypical serological profile in patients with chronic hepatitis B virus (HBV) infection. In this study, in total 94 patients with coexisting HBsAg and anti-HBs and 94 age- and sex-matched patients with positive HBsAg were characterized by quantitatively measuring HBsAg and HBV DNA, sequencing l...
متن کاملProduction, isolation, and characterization of rabbit anti-idiotypic antibodies directed against human antithyrotrophin receptor antibodies.
Previous studies have shown that anti-idiotypic antibodies can be developed in vivo through animal immunization with idiotype, and that these antibodies can be isolated from other anti-immunoglobulin antibodies by affinity purification. These techniques have relied on large amounts of idiotype, which were produced either by hyperimmunization or by monoclonal antibodies, to serve as the affinity...
متن کاملIdiotypic regulation of the immune system by the induction of antibodies against anti-idiotypic antibodies.
Anticarbohydrate antibodies (Ab1) were isolated from a rabbit hyperimmunized with Micrococcus lysodeikticus and injected into allotype-matched rabbits in order to obtain specific anti-iodiotypic antibodies (Ab2). Ab2 was isolated by means of a Sepharose column coupled to the anticarbohydrate antibodies and was injected into two allotype-matched rabbits. These latter rabbits produced specific an...
متن کاملCoexistence of hepatitis B surface antigen (HBs Ag) and anti-HBs antibodies in chronic hepatitis B virus carriers: influence of "a" determinant variants.
In chronic hepatitis B (CHB), the persistence of hepatitis B surface antigen (HBs Ag) is sometimes associated with antibodies (Ab) to HBs (anti-HBs). To assess the hypothesis of the selection of HBs Ag immune escape variants in CHB patients, the variability of the HBV S gene was determined for patients persistently carrying both HBs Ag and anti-HBs antibodies and patients solely positive for HB...
متن کامل1110 Immunization with Anti - Idiotypic Antibodies
Treatment with anti-idiotypic (anti-Id) a antibodies can, under certain experimental conditions, induce lymphocytes and antibodies of complementary specificity. Injection of minute amounts of anti-Id antibodies has been shown in several experimental systems to induce antigen-specific helper T cells (1-4) and to enhance the expression of the corresponding Id in subsequent antibody responses (5-9...
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ژورنال
عنوان ژورنال: The Tohoku Journal of Experimental Medicine
سال: 1990
ISSN: 0040-8727,1349-3329
DOI: 10.1620/tjem.161.261